RANDOMIZED CONTROLLED TRIAL OF CERVICAL-CAP WITH INTRACERVICAL RESERVOIR VERSUS STANDARD INTRACERVICAL INJECTION TO INSEMINATE CRYOPRESERVED DONOR SEMEN

A prospective controlled study of donor insemination without sperm pre paration or ovarian stimulation was performed to compare the use of a cervical cap incorporating an intracervical reservoir with a standard intracervical injection technique to inseminate 0.5 ml cryopreserved s emen, Treatments were alternated in successive cycles in each patient after initial randomized selection, A total of 198 patients had 635 tr eatment cycles (median 3, range 1-7), 309 with the reservoir and 326 b y standard injection, A total of 56 women became pregnant, 24 (7.8% pe r cycle) with the reservoir and 32 (9.8% per cycle) by injection, Ther e were no significant differences between the pregnancy rates per cycl e overall or cycle-specific cumulative rates calculated using the life -table method, There were no significant differences in age, parity, b aseline gonadotrophin measurements, mid-luteal serum progesterone conc entrations, frequency of adverse fertility factors in the woman or her partner's cause of infertility between women who conceived and those who failed to conceive, We conclude that use of a cervical reservoir a nd cap for donor insemination does not offer any advantage over standa rd intracervical insemination.