Jr. Brown et al., NATURAL CYCLE IN-VITRO FERTILIZATION WITH EMBRYO CRYOPRESERVATION PRIOR TO CHEMOTHERAPY FOR CARCINOMA OF THE BREAST, Human reproduction, 11(1), 1996, pp. 197-199
Chemotherapeutic treatment for malignant disease may cause infertility
secondary to gonadal failure, In-vitro fertilization (IVF) with embry
o cryopreservation prior to chemotherapy has been described as a means
of preserving future fertility potential. However, the supraphysiolog
ical levels of sex steroids that result from ovarian stimulation for I
VF may, at least theoretically, stimulate growth of malignant cells in
a patient with a hormonally sensitive tumour such as carcinoma of the
breast, This report describes a patient with carcinoma of the breast
who underwent IVF in the natural cycle prior to embarking on a course
of combination chemotherapy, Of three oocytes retrieved, two fertilize
d and were cryopreserved, This case represents a novel application of
IVF with embryo cryopreservation in the natural cycle. Although embryo
thawing and transfer have not yet been attempted, the patient has alr
eady benefited psychologically from having the opportunity to assume a
n element of control over her reproductive future, Should pregnancy oc
cur, this would be the first report of human pregnancy from cryopreser
ved embryos obtained in a natural cycle.