B. Spivak et al., ANTINUCLEAR AUTOANTIBODIES IN RELATION TO BIPOLAR AFFECTIVE-DISORDER AND LITHIUM-THERAPY, European psychiatry, 11(1), 1996, pp. 50-52
We investigated the presence of antinuclear antibodies (ANA) in 63 dru
g free and lithium treated bipolar patients as compared to 37 healthy
controls. Increased frequency of positive ANA was detected in bipolar
patients in comparison to controls (19% vs 5%, respectively, P < 0.05)
. This finding was unrelated to lithium treatment. No antinative DNA a
ntibodies or antihistone reactive antibodies were detected among the A
NA positive subjects.