EFFECTS OF PROSTAGLANDIN E(1) ON PLATELET -FUNCTION AND COAGULATION PARAMETERS IN PATIENTS WITH CHRONIC PERIPHERAL ARTERIAL OCCLUSIVE DISEASE

In an open study the effects of daily i.v. infusions of 60 mu g Prosta vasin(R) (PGE(1)) for 10-14 days in 12 patients with peripheral arteri al occlusive disease (stage Db) according to Fontaine on platelet func tion and some coagulation parameters have been studied. Another 5 pati ents received some concomitant drug treatment with PGE(1)-infusions. A slight but nonsignificant inhibition of platelet adhesion was observe d. Collagen- and ADP-induced aggregation did not change. Platelet indu ced thrombin generation time (PITT) was not prolonged. A slight nonsig nificant increase of fibrinogen-levels was recorded during the infusio n period. During the usual treatment of POAD with 60 mu g PGE(1) daily for two hours no increased risk of bleeding by inhibition of relevant platelet functions has to be expected.