GUANINE, PYRAZOLO[3,4-D] PYRIMIDINE, AND TRIAZOLO[4,5-D] PYRIMIDINE (8-AZAGUANINE) PHOSPHONATE ACYCLIC DERIVATIVES AS INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE

Citation
Lm. Beauchamp et al., GUANINE, PYRAZOLO[3,4-D] PYRIMIDINE, AND TRIAZOLO[4,5-D] PYRIMIDINE (8-AZAGUANINE) PHOSPHONATE ACYCLIC DERIVATIVES AS INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE, Journal of medicinal chemistry, 39(4), 1996, pp. 949-956
Citations number
21
Categorie Soggetti
Chemistry Medicinal
ISSN journal
00222623
Volume
39
Issue
4
Year of publication
1996
Pages
949 - 956
Database
ISI
SICI code
0022-2623(1996)39:4<949:GPPATP>2.0.ZU;2-C
Abstract
Phosphonate acyclic derivatives of guanines, pyrazolo[3,4-d]pyrimidine s, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of t he enzyme purine nucleoside phosphorylase (PNPase) with K-i' values ra nging from 0.05 to 1.6 mu M. These compounds are enzymatically stable congeners of the potent PNPase inhibitor acyclovir diphosphate (53).