TUMOR OXYGENATION PREDICTS FOR THE LIKELIHOOD OF DISTANT METASTASES IN HUMAN SOFT-TISSUE SARCOMA

Citation
Dm. Brizel et al., TUMOR OXYGENATION PREDICTS FOR THE LIKELIHOOD OF DISTANT METASTASES IN HUMAN SOFT-TISSUE SARCOMA, Cancer research, 56(5), 1996, pp. 941-943
Citations number
25
Categorie Soggetti
Oncology
Journal title
ISSN journal
00085472
Volume
56
Issue
5
Year of publication
1996
Pages
941 - 943
Database
ISI
SICI code
0008-5472(1996)56:5<941:TOPFTL>2.0.ZU;2-3
Abstract
This study was performed to explore the relationship between tumor oxy genation and treatment outcome in human soft tissue sarcoma. Twenty-tw o patients with nonmetastatic, high-grade, soft tissue sarcomas underw ent preoperative irradiation and hyperthermia and pretreatment measure ment of tumor oxygenation. The 18-month actuarial disease-free surviva l was 70% for patients with tumor median oxygen pressure (pO(2)) value s of >10 mm Hg but only 35% for those with median pO(2) values of <10 mm Hg (P = 0.01). There were eight treatment failures; the first site of recurrence was lung in all patients. Median pO(2) was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P = 0.03). Potential mechanisms and implications for clinical trial desig n are discussed.