CALCITONIN-GENE-RELATED PEPTIDE (CGRP) - A POTENT VASODILATOR NEUROPEPTIDE WITH NUMEROUS POTENTIAL APPLICATIONS

Authors
GRUNENBERGER F
Citation
F. Grunenberger, CALCITONIN-GENE-RELATED PEPTIDE (CGRP) - A POTENT VASODILATOR NEUROPEPTIDE WITH NUMEROUS POTENTIAL APPLICATIONS, Pathologie et biologie, 41(10), 1993, pp. 936-942
Citations number
64
Categorie Soggetti
Pathology
Journal title
Pathologie et biologie → ACNP
ISSN journal
03698114
Volume
41
Issue
10
Year of publication
1993
Pages
936 - 942
Database
ISI
SICI code
0369-8114(1993)41:10<936:CP(-AP>2.0.ZU;2-Q
Abstract
CGRP (calcitonin gene-related peptide) is a potent vasodilator neurope ptide which acts on peri-arteriolar neurones and is implicated in the pathogenesis of numerous cardiovascular diseases. The synthesis of CGR P antagonists should be useful for the treatment of Raynaud's disease as well as migraine. There exists an homology between the structures o f CGRP and pancreatic amylin and therefore an eventual role of CGRP in type II diabetes pathophysiology is currently being studied.