ACUTE BUDD-CHIARI SYNDROME WITH FULMINANT HEPATIC-FAILURE IN A PREGNANT WOMAN WITH FACTOR-V LEIDEN MUTATION

Budd-Chiari syndrome during pregnancy has rarely been reported. This r eport presents a case of acute hepatic failure in a 20-year-old pregna nt woman attributable to Budd-Chiari syndrome with underlying resistan ce to activated protein C caused by factor V Leiden mutation, The pati ent delivered a healthy girl by cesarean section in the 31st week of p regnancy, Acute hepatic failure in the 6th week postpartum was success fully treated by emergency liver transplantation, and the patient and her child were doing well at 8-month follow-up, Liver transplantation was lifesaving; normal factor V production by the transplant corrected the underlying coagulopathy. In this patient, latent thrombophilia at tributable to activated protein C resistance was apparently aggravated by the hypercoagulable state of pregnancy leading to acute Budd-Chiar i syndrome, Activated protein C resistance should be sought as an etio logic factor in patients with Budd-Chiari syndrome.