A GENETIC-CHARACTERIZATION OF DIFFERENCES IN THE SENSITIVITY TO RADIATION-INDUCED MALFORMATION FREQUENCIES IN THE MOUSE STRAINS HEILIGENBERGER, C57BI, AND HEILIGENBERGER X C57BI
Wu. Muller et al., A GENETIC-CHARACTERIZATION OF DIFFERENCES IN THE SENSITIVITY TO RADIATION-INDUCED MALFORMATION FREQUENCIES IN THE MOUSE STRAINS HEILIGENBERGER, C57BI, AND HEILIGENBERGER X C57BI, Radiation and environmental biophysics, 35(1), 1996, pp. 37-40
Citations number
12
Categorie Soggetti
Biophysics,"Radiology,Nuclear Medicine & Medical Imaging","Environmental Sciences
We studied the frequency of malformations induced in two mouse strains
(Heiligenberger, C57B1/6J) by exposure to x-rays 3 h after conception
. Whereas there was a high number of malformed fetuses in Heiligenberg
er mice (mostly gastroschises) on day 19 of pregnancy, C57B1 did not r
espond to radiation exposure shortly after conception with an increase
d frequency of malformed fetuses. Cross-breeding of both strains revea
led that no statistically significant increase in radiation-induced ma
lformations was obtained in the F-1 fetuses when the father was Heilig
enberger and the mother C57B1, In the opposite case (Heibligenberger m
other, C57B1 father) a small but statistically significant increase wa
s observed.