HYPERTHERMIA AND PARAQUAT-INDUCED G1 ARREST IN THE YEAST SACCHAROMYCES-CEREVISIAE IS INDEPENDENT OF THE RAD9 GENE

Authors
NUNES E SIEDE W
Citation
E. Nunes et W. Siede, HYPERTHERMIA AND PARAQUAT-INDUCED G1 ARREST IN THE YEAST SACCHAROMYCES-CEREVISIAE IS INDEPENDENT OF THE RAD9 GENE, Radiation and environmental biophysics, 35(1), 1996, pp. 55-57
Citations number
30
Categorie Soggetti
Biophysics,"Radiology,Nuclear Medicine & Medical Imaging","Environmental Sciences
Journal title
Radiation and environmental biophysics → ACNP
ISSN journal
0301634X
Volume
35
Issue
1
Year of publication
1996
Pages
55 - 57
Database
ISI
SICI code
0301-634X(1996)35:1<55:HAPGAI>2.0.ZU;2-4
Abstract
Mutants of the RAD9 gene of Saccharomyces cerevisiae are defective in cell cycle checkpoint arrest in G1 and G2 after treatment with DNA-dam aging agents. It is demonstrated that the pronounced G1 arrest observe d in yeast after hyperthermia treatment or exposure to paraquat-genera ted superoxide radicals does not depend on a functional RAD9 gene. For both types of treatments, the mechanism of cell cycle arrest must be considered different from the activation of the DNA damage checkpoint response.