SINGLET OXYGEN PHOTOSENSITIZING PROPERTIES OF BITHIOPHENE AND TERTHIOPHENE DERIVATIVES

An extensive set of thiophene derivatives has been evaluated to determ ine their sensitized quantum yields for singlet oxygen generation in s olution. The values have been determined using laser excitation and ti me-resolved detection of the near-IR phosphorescence from singlet oxyg en. Values determined in this work, cited in earlier publications and thesis dissertations, as well as those in the literature have been com bined in an extensive set of tables providing an up-to-date compilatio n of these efficiencies. These values are independently being used to derive quantitative structure-activity relationships (QSARs) whereby a n optimum set of physical parameters for the phototoxicity to a desire d target organism may be ascertained.