3 NOVEL REARRANGED CHOLESTANE GLYCOSIDES FROM ORNITHOGALUM-SAUNDERSIAE BULBS AND THEIR CYTOSTATIC ACTIVITIES ON LEUKEMIA HL-60 AND MOLT-4 CELLS

Authors
MIMAKI Y KURODA M SASHIDA Y HIRANO T OKA K DOBASHI A KOSHINO H UZAWA J
Citation
Y. Mimaki et al., 3 NOVEL REARRANGED CHOLESTANE GLYCOSIDES FROM ORNITHOGALUM-SAUNDERSIAE BULBS AND THEIR CYTOSTATIC ACTIVITIES ON LEUKEMIA HL-60 AND MOLT-4 CELLS, Tetrahedron letters, 37(8), 1996, pp. 1245-1248
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
8
Year of publication
1996
Pages
1245 - 1248
Database
ISI
SICI code
0040-4039(1996)37:8<1245:3NRCGF>2.0.ZU;2-2
Abstract
Three novel rearranged cholestane glycosides (1-3) were isolated form Ornithogalum saundersiae bulbs. Their structures were determined by sp ectroscopic analysis. The conformation of the E-ring part of the chole stanes was studied through molecular mechanics and molecular dynamics calculation methods. Compound 3 embracing an acyl group at the sacchar ide part strongly suppressed the growth of leukemia HL-60 cells, which was mediated partially through induction of apoptosis.