Y. Mimaki et al., 3 NOVEL REARRANGED CHOLESTANE GLYCOSIDES FROM ORNITHOGALUM-SAUNDERSIAE BULBS AND THEIR CYTOSTATIC ACTIVITIES ON LEUKEMIA HL-60 AND MOLT-4 CELLS, Tetrahedron letters, 37(8), 1996, pp. 1245-1248
Three novel rearranged cholestane glycosides (1-3) were isolated form
Ornithogalum saundersiae bulbs. Their structures were determined by sp
ectroscopic analysis. The conformation of the E-ring part of the chole
stanes was studied through molecular mechanics and molecular dynamics
calculation methods. Compound 3 embracing an acyl group at the sacchar
ide part strongly suppressed the growth of leukemia HL-60 cells, which
was mediated partially through induction of apoptosis.