ANDRASTINS A-SIMILAR-TO-C, NEW-PROTEIN FARNESYLTRANSFERASE INHIBITORS, PRODUCED BY PENICILLIUM SP FO-3929

Authors
SHIOMI K UCHIDA R INOKOSHI J TANAKA H IWAI Y OMURA S
Citation
K. Shiomi et al., ANDRASTINS A-SIMILAR-TO-C, NEW-PROTEIN FARNESYLTRANSFERASE INHIBITORS, PRODUCED BY PENICILLIUM SP FO-3929, Tetrahedron letters, 37(8), 1996, pp. 1265-1268
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
8
Year of publication
1996
Pages
1265 - 1268
Database
ISI
SICI code
0040-4039(1996)37:8<1265:AANFI>2.0.ZU;2-3
Abstract
New protein famesyltransferase inhibitors, andrastins A similar to C ( 1 similar to 3) have been isolated from the cultured broth of Penicill ium sp. FO-3929. The structure of 1 enriched by [1,2-C-13]acetate was elucidated by INADEQUATE and C-13-C-13 spin decoupling experiments. Th e structure of 2 and 3 were also elucidated by NMR experiments. Andras tins had an ent-5 alpha-14 beta-androstane skeleton with keto-enol tau tomerism.