PREPARATION OF -2-ALLYL-6-ALKYL(ARYL)-1,2,3,6-TETRAHYDROPYRIDINES BY REDUCTIVE TRANS-2,6-DIALKYLATION OF PYRIDINE - SYNTHESIS OF (+ -)-EPIDIHYDROPINIDINE/
Yn. Bubnov et al., PREPARATION OF -2-ALLYL-6-ALKYL(ARYL)-1,2,3,6-TETRAHYDROPYRIDINES BY REDUCTIVE TRANS-2,6-DIALKYLATION OF PYRIDINE - SYNTHESIS OF (+ -)-EPIDIHYDROPINIDINE/, Tetrahedron letters, 37(8), 1996, pp. 1317-1320
A convenient method for the preparation of the title compounds involvi
ng the sequential treatment of pyridine with RLi (R = Alk, Ar), triall
ylborane and methanol is developed.