BIOCHEMICAL AND CLINICAL-STUDY OF MUSCLE ATROPHY AT THENAR AND HYPOTHENAR EMINENCES IN PATIENTS WITH CIRRHOSIS

The results of various biochemical examinations in 14 patients with ci rrhosis (6 males and 8 females) with muscle atrophy at the thenar and hypothenar eminence (muscle atrophy group; mAG) were compared with tho se in 13 patients (8 males and 5 females) with cirrhosis without muscl e atrophy at these sites (non-muscle atrophy group; NmAG). All patient s were elderly men and women (mAG and NmAG, mean age, 69+/-3 years and 60+/-7, respectively). In most mAG patients, muscle atrophy was accom panied by palmar erythema. Muscle atrophy was histologically demonstra ted by biopsy. Furthermore, electromyography and magnetic resonance st udy of the cervical spinal cord revealed that the atrophy was of myoge nic rather than neurogenic origin, The Child-Pugh score, body mass ind ex and sex hormone level in urine (total 24 h) in the two groups were compared along with the biochemical results. There were no significant differences between the two groups in urine estrogen and testosterone levels. The urinary creatinine excretion was significantly reduced in mAG, The creatine phosphokinese, lactate dehydrogenase isoenzyme and aldolase levels in serum did not differ significantly in the two group s, whereas the serum albumin level was significantly increased in NmAG . Significant differences were observed only for the serum albumin lev el, age and body mass index. Thus, we consider that palmar muscle atro phy in patients with cirrhosis is not due to hormonal excess in serum, but may be attributable to advanced age and diminished physical stren gth.