LINKAGE MAPS OF RAT CHROMOSOME-15, CHROMOSOME-16, CHROMOSOME-17, CHROMOSOME-19 AND CHROMOSOME-X

Linkage maps of rat chromosomes 15, 16, 17, 19, and X were constructed by multipoint genetic linkage analysis of 22 polymorphic markers in 4 0 F-2 progeny of Fischer (F344/N) and Lewis (LEW/N) inbred rat strains . These markers are associated with eight genes (angiotensin receptor A, M3 muscarinic acetylcholine receptor, heme oxygenase, endothelin re ceptor A, haptoglobin, tyrosine aminotransferase, phosphoribosylpyroph osphate synthetase subunit II, and hosphofructo-2-kinase/fructose-2,6- bisphosphatase) and 14 anonymous loci. Linkage analysis placed the mar kers into five linkage groups covering 11.7, 7.9, 11.6, 42.5, and 5.1 cM. These linkage groups were assigned to rat chromosomes 15, 16, 17, 19, and X, respectively, either by mouse x rat somatic cell hybrid ana lysis or based on previously identified locations of several loci. In polymorphism analysis, these markers exhibited two to nine different a lleles in 16 inbred rat strains. (C) 1996 Academic Press, Inc.