IDENTIFICATION OF A KEY RECOMBINANT NARROWS THE CADASIL GENE REGION TO 8 CM AND ARGUES AGAINST ALLELISM OF CADASIL AND FAMILIAL HEMIPLEGIC MIGRAINE

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a nonarteriosclerotic, nonamyloid an giopathy characterized by recurrent subcortical ischemic strokes start ing in midadulthood and frequently leading to pseudobulbar palsy and d ementia. The disease locus has recently been mapped to chromosome 19q1 2. We have identified a chromosomal crossover in a clinically affected family member, which refines the localization of the CADASIL disease locus. Multipoint linkage analysis established the best estimate for t he gene locus within an 8-cM interval bracketed by D195226 and D19S222 . This estimate strongly argues against allelism of CADASIL and famili al hemiplegic migraine. (C) 1996 Academic Press, Inc.