FURTHER GENETIC-VARIABILITY OF THE VNTR D1S80 (PMCT118) - CORRESPONDENCE-ANALYSIS STUDIES

A population genetic study of the VNTR D1S80 (pMCT118 locus) in 206 in dividuals from the Galician population in Spain was carried out. PCR a mplified DNA were electrophoresed in horizontal polyacrylamide gels an d subsequently were visualized by silver staining, Up to 19 alleles in 56 different genotypes were found. This report describes a new allele tentatively named T11 that defines the lower limit of repeats reporte d for this VNTR, A family study demonstrates autosomal codominant inhe ritance of this allele. Levels of heterozygosity indexes are about 80% , No significant deviations from Hardy-Weinberg equilibrium were obser ved, using the allele binning method (P > 0.3 in all cases). Correspon dence analysis shows the usefulness of D1S80 alleles in the genetic pr ofiling of human populations, with the alleles 16, 17, 21, 29, and 31 being of particular interest at different levels Of analysis. (C) 1996 Wiley-Liss, Inc.