We investigate the localization properties in a highly anisotropic and
intrinsically disordered layered material which is analogous to high-
T-c cuprates. By varying the anisotropy of the system, which is parame
terized by the interlayer hopping tp, we find a crossover from two-dim
ensional (2D) to three-dimensional (3D) behavior at a critical hopping
amplitude tp(c), where a mobility edge appears. We show that below th
e mobility edge, the anisotropic localization effect may exist for a f
inite-size system, when the ab-plane localization length is longer tha
n the system size and the c-axis localization length is shorter than t
he system size. Nevertheless, we argue that such an anisotropic locali
zation cannot account for the ''semiconductor''-like behavior of the c
-axis resistivity of high-T-c cuprates.