RECENT DEVELOPMENTS IN DNA TOPOISOMERASE-II STRUCTURE AND MECHANISM

Type II DNA topoisomerases are enzymes that are capable of transportin g one duplex DNA through another. Recent experimental results, includi ng the structure of a fragment of yeast topoisomerase II, have provide d new insights into the mechanism of the strand passage reaction. Othe r results have begun to define the role of ATP in the catalytic cycle and illuminate how DNA breaks mediated by topoisomerase II can occur.