BACTERIAL TRANSLOCATION IN EXPERIMENTAL INTESTINAL-OBSTRUCTION

In this study, bacterial translocation to the mesenteric lymph nodes ( MLN), liver and spleen and the histopathological changes in the intest ine MLN, liver and spleen were investigated in Wistar Albino rats with intestinal obstruction. The subjects were divided into three main gro ups: the control group, simple obstruction group and loop obstruction group. Each group was further subdivided into two subgroups: those who underwent repeat laparotomy at 12 h or at 24 h. No bacterial transloc ation was observed in the control group. The incidences of bacterial t ranslocation to the MLN, livers and spleens of the rats with loop obst ruction who underwent repeat laparotomy at 24 h were the highest. Acco rding to the cultured bacteria growth results, Escherichia coli was mo st abundant (48%). Most histopathological changes were observed in the MLN, livers, spleens and intestines of the rats with loop obstruction who underwent second laparotomy at 24 h.