H. Akamatsu et al., THE EFFECT OF ROXITHROMYCIN ON THE GENERATION OF REACTIVE OXYGEN SPECIES IN-VITRO, Journal of international medical research, 24(1), 1996, pp. 27-32
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
The effect of roxithromycin (ROM), a new oral semisynthetic macrolide,
on the generation of reactive oxygen species (ROS), using human neutr
ophils and a cell-free, xanthine-xanthine oxidase system was examined.
The species investigated were the superoxide radical anion (O-2(-)),
hydrogen peroxide (H2O2), and the hydroxyl radical (OH .). ROM effecti
vely inhibited the generation of O-2(-), H2O2 and OH . by human neutro
phils. On the other hand, the drug did not markedly affect the ROS lev
els generated in the xanthine-xanthine oxidase system. The present stu
dy indicates that ROM may exert an anti-inflammatory action by inhibit
ing neutrophil oxygen radical generation at the sites of inflammation.