Y. Ozkul et al., DO NONSTEROIDAL ANTIINFLAMMATORY DRUGS INDUCE SISTER-CHROMATID EXCHANGES IN T-LYMPHOCYTES, Journal of international medical research, 24(1), 1996, pp. 84-87
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
The genetic toxicity of non-steroidal anti-inflammatory drugs was inve
stigated using the sister chromatid exchange technique in cultured hum
an lymphocytes. A total of 48 patients were treated with non-steroidal
anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, indomethaci
n, diclofenac or acetylsalicylic acid) for 2 weeks, The average number
s of sister chromatid exchanges in cultured lymphocytes from the patie
nts, before and after treatment with these drugs, did not differ signi
ficantly (P > 0.05), These results indicate that treatment with non-st
eroidal anti-inflammatory drugs for 2 weeks does not induce sister chr
omatid exchanges in T lymphocytes.