KINETIC-STUDY OF BACILLUS-THURINGIENSIS VAR ISRAELENSIS IN LAB-SCALE BATCH PROCESS

Fermentations of Bacillus thuringiensis have long traditions for the p roduction of delta-endotoxin as bioinsecticide in agriculture and fore stry. A process analysis study of endoprotein production by batch ferm entation is presented in this paper. General fermentation characterist ics are given and the influence of dissolved oxygen to sporulation and toxicity is discussed. Kinetics of growth and product formation is ex amined and a model based on Monod with an inhibition constant is used to describe the process. The model should provide a useful framework f or further process verification and optimisation in practice.