ALTERATION OF GTP-BINDING PROTEINS IN OVARIAN-TUMORS (REVIEW)

GTP-binding proteins (G proteins) couple cell surface receptors to gen eration of a variety of intracellular second messengers. The mutant G protein products may be responsible for trapping the protein in its ac tive and subsequently the abnormal growth of malignant cells and dysfu nction. We present recent examples of G protein gene mutations in ovar ian tumors and illustrate how such defects might lead to abnormal tumo r proliferation.