EFFECTS OF A NEW ANTIULCER AGENT, ECABET SODIUM ON A CUTANEOUS TUMORIGENESIS INDUCED WITH 7,12-DIMETHYLBENZ(A)ANTHRACENE IN MICE

A new antiulcer agent, ecabet sodium is one of dehydroabietic acid der ivatives prepared from pine resin, and is known to have a potent prote ctive effect on gastric hemorrhagic lesions induced with carcinogens b y covering a gastric mucosa after oral administration. In the present study, we investigated the effects of synthetic ecabet sodium on cutan eous tumorigenesis and development of skin-tumors induced by 7,12-dime thylbenz(a)anthracene application on mouse back skin. It was tentative ly concluded that ecabet sodium reduced the incidence of skin-tumors ( squamous cell papillomas) by inhibition of DNA synthesis in de novo pa thway, and suppressed the development of papillomas by decrease of DNA synthesis in a salvage pathway.