MULTIPLE SITES OF LOSS OF HETEROZYGOSITY ON CHROMOSOME ARMS 3P AND 3QIN HUMAN BREAST CARCINOMAS

Authors
KERANGUEVEN F NOGUCHI T WARGNIEZ V ALLIONE F GENEIX J JACQUEMIER J THEILLET C SOBOL H BIRNBAUM D
Citation
F. Kerangueven et al., MULTIPLE SITES OF LOSS OF HETEROZYGOSITY ON CHROMOSOME ARMS 3P AND 3QIN HUMAN BREAST CARCINOMAS, Oncology Reports, 3(2), 1996, pp. 313-316
Citations number
36
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
3
Issue
2
Year of publication
1996
Pages
313 - 316
Database
ISI
SICI code
1021-335X(1996)3:2<313:MSOLOH>2.0.ZU;2-L
Abstract
Loss of heterozygosity (LOH) at loci from both arms of chromosome 3 we re shown to occur in a high proportion of breast carcinomas. Six regio ns of consistent loss were identified, and were variably involved in t he tumors. This suggests that multiple potential tumor suppressor gene s involved in mammary carcinogenesis are present on chromosome 3.