THE EHRLICH ASCITES-CARCINOMA (EAC) CONTAINS 300-500 DA INHIBITOR(S) SUPPRESSING DNA-SYNTHESIS IN CULTURED EAC CELLS AND EAC CELL-DIVISION IN TUMOR-BEARING MICE

Authors
GEMBITSKY DS POPOVA NY ANTOKHIN AI PODUSOV YN KARPETS LZ ADRIANOV NV ROMANOV YA
Citation
Ds. Gembitsky et al., THE EHRLICH ASCITES-CARCINOMA (EAC) CONTAINS 300-500 DA INHIBITOR(S) SUPPRESSING DNA-SYNTHESIS IN CULTURED EAC CELLS AND EAC CELL-DIVISION IN TUMOR-BEARING MICE, Oncology Reports, 3(2), 1996, pp. 333-338
Citations number
35
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
3
Issue
2
Year of publication
1996
Pages
333 - 338
Database
ISI
SICI code
1021-335X(1996)3:2<333:TEA(C3>2.0.ZU;2-#
Abstract
A protein preparation obtained from the Ehrlich ascites carcinoma (EAC ) by acetone precipitation, water extraction and subsequent two-step a lcohol fractionation reduced significantly EAC cell proliferation in v ivo and ill vitro. The preparation was found to contain a low molecula r-weight growth-inhibitory activity, suppressing both DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice. The a pproximate molecular weight of this inhibitory component(s) is about 3 00-500 Da, corresponding to oligopeptide molecule(s).