Jp. Rolland et al., MOLECULAR PACKING OF HIGHLY FLUORINATED PHOSPHATIDYLCHOLINES IN MONOLAYERS, Chemistry and physics of lipids, 79(1), 1996, pp. 71-77
Surface pressure-area isotherms of a series of fluorinated DFnCmPC pho
sphatidylcholines bearing two acyl chains ended by a perfluoroalkyl Fn
tail of variable lengths were recorded at the air-water interface. Th
e limiting molecular areas (A(x)), the collapse pressures (pi(c)), the
pressures of the liquid-expanded to liquid-condensed phase transition
(pi(i)) and their associated A(c) and A(t) areas were deduced from th
ese experiments and compared to those of their hydrocarbon DMPC, DPPC
and DSPC analogs. The impact of the fluorinated tails on the character
istics of phosphatidylcholine monolayers, as well as the dependence of
the observed effects on the length of these tails and their relative
weight with respect to the whole hydrophobic chain length, i.e. the de
gree of 'fluorination' of the monolayer, is interpreted in terms of st
eric hindrance, hydrophobicity and chain-chain interaction balance.