GUANYLIN AND UROGUANYLIN - INTESTINAL PEPTIDE-HORMONES THAT REGULATE EPITHELIAL TRANSPORT

Authors
FORTE LR HAMRA FK
Citation
Lr. Forte et Fk. Hamra, GUANYLIN AND UROGUANYLIN - INTESTINAL PEPTIDE-HORMONES THAT REGULATE EPITHELIAL TRANSPORT, News in physiological sciences, 11, 1996, pp. 17-24
Citations number
15
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
11
Year of publication
1996
Pages
17 - 24
Database
ISI
SICI code
0886-1714(1996)11:<17:GAU-IP>2.0.ZU;2-K
Abstract
Guanylin and uroguanylin are peptides that activate a membrane guanyla te cyclase and control salt and water transport. intestinal bacteria s ecrete toxins that mimic the actions of these peptides, causing a secr etory form of diarrhea. Stimulation of guanylin/uroguanylin receptors in the kidney increases salt excretion. Thus guanylin and uroguanylin may regulate salt and water homeostasis.