J. Koyanagi et al., A SHORT SYNTHESIS OF 4-(3-FURYL)-4-OXOBUTANOIC ACID AND SYNTHESIS OF EGOMAKETONE, Journal of natural products, 58(12), 1995, pp. 1955-1957
3-Lithiofuran THF was added to succinic anhydride in THF to yield 4-(3
-furyl)-4-oxobutanoic acid [1]. Egomaketone [2], isolated from Perilla
frutescens was synthesized from 1 in lour steps. The isomer of 2, 5-(
3-furyl)-2-methyl-5-oxo-1-pentene [6], was also prepared from 1.