A full-length cDNA encoding a human homolog of the approx. 110-kDa sub
unit (elongin A; El A) of the RNA polymerase II transcription factor,
elongin, was isolated and sequenced. Comparison of the open reading fr
ames of the human El A cDNA and the previously characterized rat El A
cDNA [Aso et al., Science 269 (1995) 1439-1443] indicates that they ar
e 84% conserved in nucleotide sequence and encode 84% identical protei
ns.