OLFACTORY BULBECTOMY INCREASES PREPRO-GALANIN MESSENGER-RNA LEVELS INTHE RAT LOCUS-COERULEUS

Authors
HOLMES PV CRAWLEY JN
Citation
Pv. Holmes et Jn. Crawley, OLFACTORY BULBECTOMY INCREASES PREPRO-GALANIN MESSENGER-RNA LEVELS INTHE RAT LOCUS-COERULEUS, Molecular brain research, 36(1), 1996, pp. 184-188
Citations number
38
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
36
Issue
1
Year of publication
1996
Pages
184 - 188
Database
ISI
SICI code
0169-328X(1996)36:1<184:OBIPML>2.0.ZU;2-X
Abstract
The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expres sion in the locus coeruleus (LC) were examined with quantitative in si tu hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and level s of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC o nly on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.