COMBINATION THERAPY WITH GRANULOCYTE-COLONY-STIMULATING FACTOR, ALL-TRANS-RETINOIC ACID, AND LOW-DOSE CYTOTOXIC DRUGS FOR ACUTE MYELOGENOUSLEUKEMIA

Authors
USUKI K KITAZUME K ENDO M ITO K IKI S URABE A
Citation
K. Usuki et al., COMBINATION THERAPY WITH GRANULOCYTE-COLONY-STIMULATING FACTOR, ALL-TRANS-RETINOIC ACID, AND LOW-DOSE CYTOTOXIC DRUGS FOR ACUTE MYELOGENOUSLEUKEMIA, Internal medicine, 34(12), 1995, pp. 1186-1189
Citations number
22
Categorie Soggetti
Medicine, General & Internal
Journal title
Internal medicine → ACNP
ISSN journal
09182918
Volume
34
Issue
12
Year of publication
1995
Pages
1186 - 1189
Database
ISI
SICI code
0918-2918(1995)34:12<1186:CTWGFA>2.0.ZU;2-P
Abstract
A 67-year-old man presented with acute myelogenous leukemia (M2), Peri pheral blood examination revealed a leukocyte count of 1,700/mu l with 1% myeloblasts, and bone marrow aspiration showed 42.6% myeloblasts w ith Auer bodies, Culture of his marrow cells at diagnosis showed that granulocyte colony-stimulating factor (G-CSF) promoted cell proliferat ion, while all-trans retinoic acid (ATRA) inhibited the proliferative effect of G-CSF and induced differentiation. Combination therapy with G-CSF, ATRA, and low-dose cytotoxic drugs achieved complete remission without severe marrow suppression.