EVALUATION OF THE YSI-2300 GLUCOSE ANALYZER - ALGORITHM-CORRECTED RESULTS ARE ACCURATE AND SPECIFIC

Objectives: To insure commutability (equivalence) between whole blood and plasma glucose values and to assess potential interferences in glu cose oxidase methods. Design and Methods: We compared plasma glucose r esults by the Ektachem 700 analyzer to glucose results on whole blood by the Nova Stat Profile 6, and by the YSI 2300, both without hematocr it correction (YSIunc) and with two different hematocrit (Hct) correct ions. The two correction methods were: (a) whole blood results multipl ied by 1.11 (YSI1.11), and (b) whole blood results corrected for Hct w ith the programmed YSI algorithm (YSIcor). Several compounds were test ed for interference. Results: 88% of YSIcor results agreed with plasma results within +/-5%, and 78% of Nova and 74% of YSI1.11 results were within this limit. YSIcor results were unaffected by Hct and were val id even when erythrocyte size was abnormal. At low Hct, Nova results w ere falsely decreased, while YSI1.11 results were falsely elevated. Th e Ektachem was most affected by ascorbic acid, and the Nova was especi ally affected by acetaminophen. Conclusions: The YSI algorithm-correct ed whole blood glucose results were commutable with plasma results and the YSI was unaffected by the compounds tested, including acetaminoph en and acetylsalicylic acid.