INCREASED GLYCATION OF PLASMA-LIPOPROTEINS IN DIABETIC CYNOMOLGUS MONKEYS

Hyperglycemia associated with diabetes mellitus increases glycation of hemoglobin and serum proteins in human and nonhuman primates, It also has been documented that numerous other circulating proteins may be g lycated, In this study we found that most of the major subclasses of L ipoproteins (low-density, very low-density, and high-density) from dia betic cynomolgus monkeys were significantly more glycated than were li poproteins from age- and sex-matched controls, Correlations between le vels of glycemic control and glycation of lipoproteins also were signi ficant. Because glycation of lipoproteins has been shown to affect the ir normal metabolism, this animal model may be useful in determining t he interaction between lipoproteins, diabetes mellitus, and the increa sed risk of atherosclerosis.