INTRAUTERINE INSEMINATION WITH FROZEN SPERM INCREASES PREGNANCY RATESIN DONOR INSEMINATION CYCLES UNDER GONADOTROPIN STIMULATION

Objective: To compare the efficacy of IUI donor and pericervical insem ination donor in frozen sperm insemination cycles under gonadotropin s timulation. Design: Couples where infertility was caused by male condi tions were randomized into two groups: IUI and pericervical inseminati on. Semen samples, gonadotropin stimulation, and ovarian monitoring we re the same in both groups. One IUI was performed per cycle as against two pericervical inseminations. Setting: The donor insemination progr am at the Human Reproduction Unit at the Hospital of Cruces, Pais Vasc o University. Patients: Eighty-eight women (47 IUI and 41 pericervical insemination) with at least one patent fallopian tube and <40 years o f age. Main Outcome Measure: Intrauterine gestational sac observed by transvaginal ultrasound. Results: Per woman pregnancy rate (PR) was hi gher in IUI than in pericervical insemination (65.96% versus 41.46%, o dds ratio [OR] = 2.73, confidence interval [CI] = 1.06 to 7.2). Pregna ncy rates were always higher in IUI irrespective of woman and husband' s status, but statistical significance was not reached in any subgroup s analyzed independently. Per cycle PR was also significantly higher i n IUI than in pericervical insemination: 24.03% (31/129) versus 11.89% (17/143) (OR = 2.34, CI = 1.17 to 4.71). Moreover, cumulative PR was higher in IUI(86% versus 49.5%) (OR = 6, CI = 1.98 to 18.80). Conclusi on: Per woman and per cycle PRs were significantly higher in IUI.