The diagnosis of movement disorders is essentially clinical. Work-up d
epends on patient age, part of the body affected, drug response, and p
resence of other systemic or neurologic symptoms and signs. Typical Pa
rkinson's disease, essential tremor, and ties need only minimal work-u
p if any. Brain magnetic resonance imaging/computed tomography, positr
on emission tomography and single photon emission computed tomography,
and DNA studies are promising diagnostic tools. Exclusion of Wilson's
disease and neuroacanthocytosis is emphasized in children and young a
dults with movement disorders.