STUDIES ON THE DIMERIZATION OF MELATONIN (5-METHOXY-N-ACETYLTRYPTAMINE) AND RELATED-COMPOUNDS IN ACID-MEDIUM - OXIDATION OF SOME 2-ARYLINDOLINES INTO 2-ARYLINDOLES

Authors
CHARLETFAGNERE C LARONZE J LARONZE JY TOUPET L VISTELLE R LAMIABLE D MOUCHARD C RENARD P ADAM G
Citation
C. Charletfagnere et al., STUDIES ON THE DIMERIZATION OF MELATONIN (5-METHOXY-N-ACETYLTRYPTAMINE) AND RELATED-COMPOUNDS IN ACID-MEDIUM - OXIDATION OF SOME 2-ARYLINDOLINES INTO 2-ARYLINDOLES, Bulletin de la Societe chimique de France, 133(1), 1996, pp. 39-50
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology,Chemistry
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
133
Issue
1
Year of publication
1996
Pages
39 - 50
Database
ISI
SICI code
0037-8968(1996)133:1<39:SOTDOM>2.0.ZU;2-#
Abstract
Studies on the dimerization of melatonin (5-methoxy-N-acetyltryptamine ) and related compounds in acid medium. Oxidation of some 2-arylindoli nes into 2-arylindoles. Acid treatment of 5-methozy-N-acetyltryptamine (melatonin) and other related derivatives 1 gave compounds 2 (2,2'-di mers) or 4 (2,6'-dimers). Compounds 2, which easily revert to monomers 1, could be considered as potential prodrugs of melatonin. (prelimina ry in vitro and in vivo pharmacological data are given). Finally, the oxidation of dimers 2 and 4 to bisindoles 10 and 12 is considered.