CHEMICALLY-INDUCED ANEUPLOIDY IN MAMMALIAN OOCYTES

The ability of certain chemicals to elevate the frequency of aneuploid y above spontaneous levels in mammalian experimental models prompts th e concern that a similar situation might exist in humans. Validation o f experimental models for aneuploidy studies is in progress since ther e is much to be learned about the causes and mechanisms of chemically- induced aneuploidy. Several biological variables have been shown to in fluence the results from aneuploidy assays. In this review, we examine these variables as they relate to female germ cell aneuploid assays. Also, we have found that the aneuploidy results obtained from differen t cell types, sexes, and experimental models cannot necessarily be exp ected to agree due to certain anatomic and physiologic differences and the end points measured.