PRENATAL-DIAGNOSIS OF ROBERTS-SYNDROME - 2 NEW CASES

We report two fetuses with typical anomalies of Roberts syndrome. Pren atal diagnosis was confirmed by the characteristic disjunction of cent romeres in amniocytes. We compare these cases with a child who present ed with severe Roberts syndrome. We attempted to evaluate quantitative ly the centromeric abnormality and the chromosome separation in the di fferent cultures and with different methods. The variability of the cl inical manifestations and cytogenetic investigations of this syndrome are reviewed.