SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY OF DIORGANOTIN(IV)COMPLEXES WITH 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES

The coordination behaviour of the diorganotin(IV) compounds R(2)SnCl(2 ) (where R = Me, Ph) with 4H-pyrido [1,2-a] pyrimidin-4-one derivative s (L) has been described. The complexes R(2)SnCl(2) . L obtained have been characterized physicochemically and spectroscopically. The pyrimi din-4-one ligands were found to coordinate with R(2)SnCl(2) species in a monodentate fashion, mainly via the oxygen atom of the 4-one group or possibly via the nitrogen atom of the -C=N linkage (the less steric ally hindered nitrogen of the pyrimidine derivative) to give pentacoor dinate tin complexes. Of the complexes selected to be screened against five tumour cell lines, some exhibited significant in vitro activity.