THE ENANTIOSELECTIVE OXIDATION OF SULFIDES TO SULFOXIDES WITH ACINETOBACTER SP, NCIMB-9871, PSEUDOMONAS SP, NCIMB-9872, XANTHOBACTER AUTOTROPHICUS DSM-431 (NCIMB-10811) AND THE BLACK YEAST NV-2

Authors
KELLY DR KNOWLES CJ MAHDI JG TAYLOR IN WRIGHT MA
Citation
Dr. Kelly et al., THE ENANTIOSELECTIVE OXIDATION OF SULFIDES TO SULFOXIDES WITH ACINETOBACTER SP, NCIMB-9871, PSEUDOMONAS SP, NCIMB-9872, XANTHOBACTER AUTOTROPHICUS DSM-431 (NCIMB-10811) AND THE BLACK YEAST NV-2, Tetrahedron : asymmetry, 7(2), 1996, pp. 365-368
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
2
Year of publication
1996
Pages
365 - 368
Database
ISI
SICI code
0957-4166(1996)7:2<365:TEOOST>2.0.ZU;2-D
Abstract
Whole cell oxidation of aryl alkyl sulfides to sulfoxides with Acineto bacter sp. NCIMB 9871 is only slightly less enantioselective than isol ated enzyme transformation with the cyclohexanone monooxygenase (CHMO) from the same species. Pseudomonas sp. NCIMB 9872 oxidises the same s ubstrates with high and mostly opposite enantioselectivity (73-100%ee) . CHMO activity was detected in the black yeast NV-2 and Xanthobacter autotrophicus DSM 431 (NCIMB 10811), but contrary to an earlier report this activity could not be detected in cell free extracts of the latt er. Both species oxidised methyl phenyl sulfide exclusively to the cor responding (R)-sulfoxide (100% ee).