MICROBIAL HYDROXYLATION OF 2-CYCLOALKYLBENZOXAZOLES .1. PRODUCT SPECTRUM OBTAINED FROM CUNNINGHAMELLA-BLAKESLEEANA DSM-1906 AND BACILLUS-MEGATERIUM DSM-32

Authors
DERAADT A GRIENGL H PETSCH M PLACHOTA P SCHOO N WEBER H BRAUNEGG G KOPPER I KREINER M ZEISER A KIESLICH K
Citation
A. Deraadt et al., MICROBIAL HYDROXYLATION OF 2-CYCLOALKYLBENZOXAZOLES .1. PRODUCT SPECTRUM OBTAINED FROM CUNNINGHAMELLA-BLAKESLEEANA DSM-1906 AND BACILLUS-MEGATERIUM DSM-32, Tetrahedron : asymmetry, 7(2), 1996, pp. 467-472
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
2
Year of publication
1996
Pages
467 - 472
Database
ISI
SICI code
0957-4166(1996)7:2<467:MHO2.P>2.0.ZU;2-4
Abstract
2-Cycloalkyl-1, 3-benzoxazoles and -thiazoles (ring sizes C-3 to C-8) were biotransformed using the title microorganisms. Products of prepar ative importance were (1S, 3S)-3-(benz-1, 3-oxazol-2-yl)cyclopentan-1- ol 6, (1R)-3-(benz-1, 3-oxazol-2-yl)cyclopentan-1-one 8, (1R, 2R)-2-(b enz-1, 3-oxazol-2-yl)cyclohexan-1-ol 14 and the corresponding cyclohep tanol and cycloheptanone derivatives.