URINARY CREATINE AS A POTENTIAL MARKER OF TESTICULAR DAMAGE - EFFECT OF VASECTOMY

The concentrations of creatine in the rat testis are high compared to all other tissues except muscle. The total creatine content of the tes tis is also considerably greater than all organs examined except muscl e. Vasectomised male rats were given 2-methoxyethanol or cadmium chlor ide at doses that caused testicular damage. In the vasectomised rats, testicular damage still resulted in significant creatinuria. This indi cates the creatine reaches the urine at least partly via the blood str eam and not via the vas deferens.