HARLEQUIN ICHTHYOSIS - A CASE-REPORT

The Harlequin infant represents the most severe form of nonbullous ich thyosis. Although the clinical features of infants with Harlequin icht hyosis are generally similar, histological, ultrastructural, and bioch emical analyses have not shown consistent findings. An unexpected case of Harlequin ichihyosis in a female infant born at 35 wks gestation i s presented. Light microscopic and ultrastructural investigations of s kin biopsies are detailed. The presence of extracellular lipid materia l in the stratum corneum has not been described in the previously repo rted cases of Harlequin ichthyosis.