Hospital-acquired or nosocomial infections are infections that are nei
ther present nor incubating at the time of admission. They must become
manifest by 48 h after admission. They raise significantly the morbid
ity, mortality, and economic burden of the underlying disease. Nosocom
ial infections occur in 2.5-9.5% of all hospitalizations. They are mai
nly found in intensive care units and surgical wards. Urinary tract in
fections are the most frequent, followed by wound infections, pneumoni
a, infections of the skin and mucosa, bloodstream infections and other
s. The major pathogens causing nosocomial infections are Staphylococcu
s aureus, Escherichia coli, enterococcus and Pseudomonas. Methicillin-
resistant pathogens must be considered. In Germany the direct costs of
excessive hospital stays exceed 3 billion DM annually. Preventive mea
sures reduce current nosocomial infections. The CDC suggest that these
measures include a trained hospital epidemiologist, an infection cont
rol nurse, an active surveillance program and data feedback to surgeon
s about their wound infection rates.