ACROMEGALIC PREGNANCY-ASSOCIATED WITH A BECKWITH-WIEDEMANN FETUS

Beckwith-Wiedemann syndrome is a rare serious condition with a high ra te of malignant tumors. A relationship between Beckwith-Wiedemann synd rome and insulin-like growth factor (IGF) II gene located at the level of the 11p15 chromosomic region has been demonstrated. Case: An acrom egalic woman (elevated IGF I serum levels) undergoing pregnancy with a Beckwith-Wiedemann fetus is reported. We therefore reviewed data abou t this association and particularly fetal growth, and analyzed fetal b lood samples for IGF I and Acromegaly II. Conclusion: We conclude that this association (i.e. Beckwith-Wiedemann syndrome and acromegaly) is independent, and point out that IGF I and II might be very high in th e Beckwith-Wiedemann fetus.