HUMAN INSULIN-INDUCED LIPOATROPHY - SUCCESSFUL TREATMENT USING A JET-INJECTION DEVICE

OBJECTIVE - To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insuli n-induced lipoatrophy. CASE - We report a case of a woman with severe human insulin-induced lipoatrophy vi ho has been treated exclusively w ith recombinant DNA human insulin since the onset of IDDM. RESULTS - T he loss of subcutaneous tissue in the injection areas was demonstrated and measured by high-frequency ultrasound. Dermatologic exam demonstr ated a severe reduction of fat tissue. After 8 months of administratio n of human insulin by a jet injector, there were no more new lesions o f lipoatrophy and those affected areas were substantially ameliorated. CONCLUSIONS - Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipo atrophy.