C. Susal et al., DOES AIDS EMERGE FROM A DISEQUILIBRIUM BETWEEN 2 COMPLEMENTARY GROUPSOF MOLECULES THAT MIMIC MHC, Immunology today, 17(3), 1996, pp. 114-119
Ther is increasing evidence that a disturbance of self-nonself-recogni
tion plays an important role in the immunopathogenesis of AIDS. Here,
Cancer Susal, Volker Daniel and Gerhard Opelz speculate that the immun
e system is balanced between two groups of molecules that mimic major
histocompatibility complex (MHC) proteins; AIDS is suggested to emerge
as a consequence of human immunodeficiency virus (HIV) disturbing thi
s balance in favor of anti-MHC class II responses.